SMAC Cape Town first opened in 2011, with the gallery relocating to its current flagship space in Woodstock, in 2014, and SMAC Johannesburg opening in 2016. The gallery's programme is focused on representing leading and emerging contemporary artists from Africa. In addition to its contemporary programme, SMAC Stellenbosch regularly presents large-scale historical exhibitions and projects that offer a critical re-evaluation of South African art history within a global dialogue.
SMAC participates in between 10 – 12 international fairs per year, including The Armory Show, Art Brussels, Artissima, artmonte-carlo, and Miart. The gallery maintains an active publishing initiative.